Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps
نویسندگان
چکیده
منابع مشابه
Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps
BACKGROUND Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are released from T cells, innate lymphoid cells (ILC) are also known to produce high levels of the same cytokines. However, the presence of various types of ILC in CRS is poorly understood. OBJECTIVE The objective of this st...
متن کاملInterleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.
Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases. However, patients receiving IL-2 treatment also experience eosinophilia due to an unknown mechanism. Here, we show that patients receiving low-dose IL-2 have elevated levels of serum IL-5, and this correlates with their degree of eosinophilia. ...
متن کاملRole of Interleukin-10 on Nasal Polypogenesis in Patients with Chronic Rhinosinusitis with Nasal Polyps
BACKGROUND AND OBJECTIVES Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. The dysregulation of IL-10 is associated with an enhanced immunopathologic response to infection, as well as with an increased risk for developing numerous autoimmune diseases. In this study, we investigated IL-10 expression in chronic rhinosinusitis with nasal polyps (CRSwNP) and assessed the possible role...
متن کاملCorrection: Role of Interleukin-10 on Nasal Polypogenesis in Patients with Chronic Rhinosinusitis with Nasal Polyps
[This corrects the article DOI: 10.1371/journal.pone.0161013.].
متن کاملSymptoms in chronic rhinosinusitis with and without nasal polyps.
OBJECTIVES/HYPOTHESIS In this study we analyzed differences in symptoms scored between chronic rhinosinusitis patients with (CRSwNP) and without nasal polyps (CRSsNP). According to the European Position Paper on Rhinosinusitis and Nasal Polyps, CRSwNP and CRSsNP diagnoses are defined by clinical criteria supported with endoscopy. We wanted to know if it is possible to make an accurate distincti...
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ژورنال
عنوان ژورنال: International Forum of Allergy & Rhinology
سال: 2018
ISSN: 2042-6976
DOI: 10.1002/alr.22142